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Introduction: Schizophrenia is a complex mental health condition characterized by disruptions in thought processes, perception, emotional responsiveness, and social interactions. Understanding the pathogenesis of schizophrenia is crucial for identifying the underlying mechanisms that contribute to its development. This knowledge provides a foundation for effective prevention and intervention strategies. For individuals seeking treatment for Schizophrenia, consider consulting qualified mental health professionals such as: https://www.bestpsychiatristsindelhi.com/ https://www.delhimindclinic.com/ 1. Genetic Factors in the Pathogenesis of Schizophrenia Genetic predisposition plays a pivotal role in the pathogenesis of schizophrenia. Research shows that individuals with a family history of schizophrenia have a significantly higher risk of developing the condition. Twin and adoption studies estimate that genetic factors account for up to 80% of the risk. Specific genetic variations, particularly those that influence neurotransmitter systems, may disrupt brain development and function. However, while genetic predisposition increases vulnerability, it is not the sole determinant, as other factors interact to contribute to schizophrenia.